By Clinton Colmenares
Photography by  Josh Wilson

Rodrigo Martinez-Duarte is using bacteria to create advanced materials

In his lab at Clemson University, mechanical engineer Rodrigo Martinez-Duarte and his students are coaxing bacteria into weaving materials.

“We’re trying to use bacteria as a factory” says Martinez-Duarte, an associate professor in the College of Engineering, Computing and Applied Sciences.

Not just any factory, but a tiny 3D printers of sorts, weaving cellulose fibers into engineered films with a multitude of potential uses, from sensors to battery capacitors to scaffolding for human tissue. The goal is a cleaner, more sustainable material than those currently made from petroleum, like plastic.

For a university with a rich history in textile engineering, it’s fitting that futuristic bacterial nanoweaving has its roots here. And Martinez-Duarte sees unlimited growth potential with highly customized materials.

“Once you have full control of the structure, you can start changing the physical and chemical properties of the structure itself,” he says.

Martinez-Duarte has already established a name for himself among peers by carving out a niche: he’s a mechanical engineer using electrical engineering techniques on living organisms to make advanced materials.

“He’s pushing things forward and is one of the most promising people in our field,” says Rafael Davalos, a professor of biomedical engineering and mechanics at Virginia Tech.

GO TO THE LIGHT

In his Multiscale Manufacturing Lab, students feed acetobacter bacteria a steady diet of sugar water. The bacteria “eat” the sugar water and turn it into cellulose, the same stuff found in trees and cotton. Left to its own devices, the byproduct is a mass of fibers that congeals into what’s technically known as a pellicle: a blob that looks like wet bread.

The challenge is transforming the randomly structured blob into something more useful by wrangling the cells into a more regimented formation. First, the cells have to be separated, which, at the moment, can only be done one at a time. Ultimately, Martinez-Duarte wants to move a whole army of cells, each one marching along specific lines — up, down, over, weaving in and out of each other — laying down cellulose thread as they go.

He’s making steady progress by sorting the cells with a technology called light-induced dielectrophoresis, which uses electric fields to exploit the cells’ natural inclination of attraction or repulsion to electric field gradients.

Martinez-Duarte and his team generate these electric field gradients using light patterns created with a light projector coupled to precise optics. Cells respond to such a gradient by moving either toward or away from it. In videos of their work, cells are seen separating from a cluster and following the light, like a cat chasing a laser pointer.

After showing basic movement of the acetobacter bacteria, Martinez-Duarte is now working to implement designed trajectories using fungal cells.

SORTING CELLS FOR HUMANITY’S SAKE

Martinez-Duarte is standing at the dawn of a new age — the Age of Nanoweavers. There are objects, devices, structures to be made, and he’s cogitating on how to make their fundamental building blocks in ways never imagined, much less carried out.

In addition to the cellulose fiber work, Martinez-Duarte and his students are using similar principles to sort cells for biomedical applications. If they can successfully separate one or two pathogenic cells from blood or urine samples, without expensive and bulky lab equipment, it would not only be an engineering success, but also an economical and humanitarian success.

Currently, he and his students are focusing on sorting the different kinds of Candida that can cause a yeast infection, an increasing problem around the world because the yeast are becoming resistant to current drugs. Using electric fields and microfluidics, Martinez-Duarte and his team are working toward a test that sorts the infecting cells so they can be quickly identified and physicians can target treatments to specific strains. This latest work on Candida comes after work with blood cells, parasites, bacteria and DNA in the last 10 years and in collaboration with multiple groups around the world.

“For someone who is an engineer doing biomedical work, [Martinez-Duarte’s research] is pretty fantastic,” says Blanca Lapizco-Encinas, a professor of biomedical engineering at the Rochester Institute of Technology.

Martinez-Duarte is driven by a desire to make the world a better place. It’s a sense of responsibility that was fostered by his parents while growing up in Sinaloa, Mexico. His father influenced his interest in engineering, and his mother always encouraged him “to persevere towards my goals, to enjoy hard work and always strive for my best work,” he says. These are principles he strives to pass on to his mentees.

There are plenty of technical challenges to overcome before Martinez-Duarte’s work becomes common. The team is learning how to characterize each cell’s electrical signature in order to move them individually. They’re deciding which bacteria to use, what to feed it and the conditions under which the cells could produce cellulose with tailored properties. That’s the way science works; questions are asked and answered, examined, answered again, more questions are asked, ways to test theories are invented. It takes years to build a factory, especially one nobody, except Martinez-Duarte, has ever imagined before.

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